Physiological basis for a causal relationship of obstructive sleep apnoea to hypertension.

@article{Weiss2007PhysiologicalBF,
  title={Physiological basis for a causal relationship of obstructive sleep apnoea to hypertension.},
  author={J. Woodrow Weiss and M D Yuzhen Liu and Jianhua Huang},
  journal={Experimental physiology},
  year={2007},
  volume={92 1},
  pages={21-6}
}
Obstructive sleep apnoea (OSA) is causally related to systemic hypertension through sustained sympathoexcitation. The causes of this sympathoexcitation remain uncertain; however, substantial animal and human data suggest that cyclic intermittent hypoxia (CIH), as is experienced at night by patients with OSA, provides the causal link between upper airway obstruction during sleep and sympathetic activation during waking. Direct and indirect evidence indicates that CIH leads to sympathoexcitation… CONTINUE READING
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