Physiological barriers to the oral delivery of curcumin.

  title={Physiological barriers to the oral delivery of curcumin.},
  author={Katja Berginc and Jurij Trontelj and N Skalko Basnet and Albin Kristl},
  journal={Die Pharmazie},
  volume={67 6},
Curcumin, a principal component from Curcuma longa, with antioxidant and anti-inflammatory activities was proposed as a potential candidate for the preventation and/or treatment of cancer and chronic diseases. However, curcumin could not achieve its expected therapeutic outcome in clinical trials due to its low solubility and poor bioavailability. The actual intestinal physiological barriers limiting curcumin absorption after oral administration have not been fully investigated. To identify the… CONTINUE READING
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