Physiological aspects of high-altitude pulmonary edema.

@article{Brtsch2005PhysiologicalAO,
  title={Physiological aspects of high-altitude pulmonary edema.},
  author={Peter B{\"a}rtsch and Heimo Mairb{\"a}url and Marco Maggiorini and Erik R. Swenson},
  journal={Journal of applied physiology},
  year={2005},
  volume={98 3},
  pages={
          1101-10
        }
}
High-altitude pulmonary edema (HAPE) develops in rapidly ascending nonacclimatized healthy individuals at altitudes above 3,000 m. An excessive rise in pulmonary artery pressure (PAP) preceding edema formation is the crucial pathophysiological factor because drugs that lower PAP prevent HAPE. Measurements of nitric oxide (NO) in exhaled air, of nitrites and nitrates in bronchoalveolar lavage (BAL) fluid, and forearm NO-dependent endothelial function all point to a reduced NO availability in… 

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