Physiological and proteomic analysis of Escherichia coli iron-limited chemostat growth.

  title={Physiological and proteomic analysis of Escherichia coli iron-limited chemostat growth.},
  author={James P. Folsom and Albert E. Parker and Ross P. Carlson},
  journal={Journal of bacteriology},
  volume={196 15},
Iron bioavailability is a major limiter of bacterial growth in mammalian host tissue and thus represents an important area of study. Escherichia coli K-12 metabolism was studied at four levels of iron limitation in chemostats using physiological and proteomic analyses. The data documented an E. coli acclimation gradient where progressively more severe iron scarcity resulted in a larger percentage of substrate carbon being directed into an overflow metabolism accompanied by a decrease in biomass… CONTINUE READING
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