Physiological and pharmacological properties of 5-HT3 receptors--a patch clamp-study.

  title={Physiological and pharmacological properties of 5-HT3 receptors--a patch clamp-study.},
  author={H M Malone and John A. Peters and J J Lambert},
  volume={19 Suppl},
Whole cell and patch clamp techniques were used to investigate the properties of 5-HT3 receptors of a murine neuroblastoma cell line (N1E-115) and adult rabbit nodose ganglion neurones. In addition, some preliminary results from guinea-pig nodose ganglion neurones are presented. In such cells, voltage-clamped at -60 mV, 5-HT (10 microM) induced an inward current associated with a conductance increase. The results of ion substitution experiments suggest that the 5-HT activated ion channel is… CONTINUE READING


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