Physiological and pharmacological influences on thyroxine to 3,5,3'-triiodothyronine conversion and nuclear 3,5,3'-triiodothyronine binding in rat anterior pituitary.

@article{Cheron1979PhysiologicalAP,
  title={Physiological and pharmacological influences on thyroxine to 3,5,3'-triiodothyronine conversion and nuclear 3,5,3'-triiodothyronine binding in rat anterior pituitary.},
  author={R. Cheron and M. Kaplan and P. Larsen},
  journal={The Journal of clinical investigation},
  year={1979},
  volume={64 5},
  pages={
          1402-14
        }
}
  • R. Cheron, M. Kaplan, P. Larsen
  • Published 1979
  • Biology, Medicine
  • The Journal of clinical investigation
  • Our recent in vivo studies have suggested that intrapituitary l-thyroxine (T(4)) to 3,5,3'-triiodo-l-thyronine (T(3)) conversion with subsequent nuclear binding of T(3) is an important pathway by which circulating T(4) can inhibit thyrotropin release. The present studies were performed to evaluate various physiological and pharmacological influences on these two processes in rat anterior pituitary tissue. Intact pituitary fragments were incubated in buffer-1% bovine serum albumin containing 0… CONTINUE READING

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