Physiological and pathological roles of the mitochondrial permeability transition pore in the heart.

Abstract

Prolonged mitochondrial permeability transition pore (MPTP) opening results in mitochondrial energetic dysfunction, organelle swelling, rupture, and typically a type of necrotic cell death. However, acute opening of the MPTP has a critical physiologic role in regulating mitochondrial Ca(2+) handling and metabolism. Despite the physiological and pathological… (More)
DOI: 10.1016/j.cmet.2014.12.001

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Cite this paper

@article{Kwong2015PhysiologicalAP, title={Physiological and pathological roles of the mitochondrial permeability transition pore in the heart.}, author={Jennifer Q Kwong and Jeffery D Molkentin}, journal={Cell metabolism}, year={2015}, volume={21 2}, pages={206-14} }