Physiological and pathological roles of interleukin-6 in the central nervous system

  title={Physiological and pathological roles of interleukin-6 in the central nervous system},
  author={Donna L. Gruol and Thomas E. Nelson},
  journal={Molecular Neurobiology},
The cytokine interleukin-6 (IL-6) is an important mediator of inflammatory and immune responses in the periphery. IL-6 is produced in the periphery and acts systemically to induce growth and differentiation of cells in the immune and hematopoietic systems and to induce and coordinate the different elements of the acute-phase response. In addition to these peripheral actions, recent studies indicate that IL-6 is also produced within the central nervous system (CNS) and may play an important role… CONTINUE READING


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