Physiological and pathological roles for microRNAs in the immune system

  title={Physiological and pathological roles for microRNAs in the immune system},
  author={Ryan M O'connell and Dinesh S. Rao and Aadel A. Chaudhuri and David Baltimore},
  journal={Nature Reviews Immunology},
Mammalian microRNAs (miRNAs) have recently been identified as important regulators of gene expression, and they function by repressing specific target genes at the post-transcriptional level. Now, studies of miRNAs are resolving some unsolved issues in immunology. Recent studies have shown that miRNAs have unique expression profiles in cells of the innate and adaptive immune systems and have pivotal roles in the regulation of both cell development and function. Furthermore, when miRNAs are… CONTINUE READING
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