Physiological and morphological effects of genistein against the liver fluke, Fasciola hepatica

@article{Toner2008PhysiologicalAM,
  title={Physiological and morphological effects of genistein against the liver fluke, Fasciola hepatica},
  author={Emma Toner and Gerard P. Brennan and K. Wells and J Graham Mcgeown and Ian Fairweather},
  journal={Parasitology},
  year={2008},
  volume={135},
  pages={1189 - 1203}
}
SUMMARY A study has been carried out to determine the activity of genistein against adult liver fluke, Fasciola hepatica. Flukes were incubated in vitro in genistein at a concentration of 0·27 mg/ml (=1 mm). They ceased to move after 3 h, at which point the experiment was terminated and the specimens prepared for examination by scanning and transmission electron microscopy. Surface changes to the flukes comprised swelling and blebbing, especially in the posterior region of the flukes, and there… 
Disruption of spermatogenesis in the liver fluke, Fasciola hepatica by two artemisinin derivatives, artemether and artesunate
TLDR
The fine structural changes occurring in the spermatogenic cells were compared to those observed in other cell types and fluke tissues and the overall information was collated to identify the cellular targets for artemisinin action and to establish the time-line for drug action.
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TLDR
An in vivo study in the laboratory rat model to monitor changes to the tegument and gut of adult Fasciola hepatica following treatment with myrrh found a trans-tegumental route of uptake for Mirazid by the fluke.
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TLDR
Results have shown that exposure to Mirazid treatment had a severe impact on egg production by TCBZ-resistant flukes, an effect that was mediated by disruption of the vitelline cells and of the mechanism co-ordinating egg formation in the ootype.
Disruption of vitellogenesis and spermatogenesis by triclabendazole (TCBZ) in a TCBZ-resistant isolate of Fasciola hepatica following incubation in vitro with a P-glycoprotein inhibitor
TLDR
The concept of altered drug efflux in TCBZ-resistant flukes supported and the results indicate that drug transporters may play a role in the development of drug resistance.
THE EFFECT OF GENISTEIN AGAINST SCHISTOSOMA MANSONI IN EXPERIMENTALLY INFECTED MICE
TLDR
There were significant reductions in the total worm number and egg load of liver and intestinewith significant decrease in immature and mature eggs in all groups received treatment in comparison with the infected non treated control one.
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