Physiological and cytokine responses in IL-1 beta-deficient mice after zymosan-induced inflammation.

@article{Fantuzzi1997PhysiologicalAC,
  title={Physiological and cytokine responses in IL-1 beta-deficient mice after zymosan-induced inflammation.},
  author={Giamila Fantuzzi and Silvano Sacco and Pietro Ghezzi and Charles A Dinarello},
  journal={The American journal of physiology},
  year={1997},
  volume={273 1 Pt 2},
  pages={R400-6}
}
Interleukin (IL)-1 beta-deficient (IL-1 beta -/-) mice exhibited decreased zymosan-induced lethality and reduced production of IL-6 compared with wild-type controls (IL-1 beta +/+). In addition, IL-1 beta -/- mice had a diminished cellular infiltrate (33%) in the peritoneal cavity after zymosan. However, anorexia and hypoglycemia were not affected by the lack of IL-1 beta. The induction of corticosterone was only slightly reduced (14%) in IL-1 beta -/- mice. Peritoneal lavage fluid levels for… CONTINUE READING

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