Physiological and clinical implications of medullary hypoxia.

@article{Epstein1987PhysiologicalAC,
  title={Physiological and clinical implications of medullary hypoxia.},
  author={Franklin H. Epstein and Mayer Brezis and Patricio da Silva and Scott Rosen},
  journal={Artificial organs},
  year={1987},
  volume={11 6},
  pages={463-7}
}
Because of countercurrent capillary flow, the renal medulla of mammalian kidneys is perpetually hypoxic, the ambient oxygen tension hovering close to the critical Po2 that limits respiration. Within this environment, the mitochondria-rich cells of the medullary thick ascending limb (mTAL) require large amounts of energy to accomplish the work of ion transport. These cells are therefore uniquely vulnerable to anoxic damage, as is demonstrated by morphological changes in isolated perfused rat… CONTINUE READING

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