Physiological and biochemical evidence for coordinate increases in muscarinic receptors and Gi during pacing-induced heart failure.

@article{Vatner1996PhysiologicalAB,
  title={Physiological and biochemical evidence for coordinate increases in muscarinic receptors and Gi during pacing-induced heart failure.},
  author={Dorothy E. Vatner and Naoki Sato and Jonas B. Galper and Stephen F. Vatner},
  journal={Circulation},
  year={1996},
  volume={94 1},
  pages={102-7}
}
BACKGROUND It is not clear whether the increase in the myocardial guanylyl nucleotide inhibitory protein (Gi), frequently observed in heart failure, is associated with any functional effects. METHODS AND RESULTS Eight sham-operated dogs and 10 dogs were studied with pacing-induced heart failure (240 bpm for 4 to 7 weeks), characterized by reduced (P<.05) left ventricular dP/dt (from 2926+/-99 to 1303+/-126 mm Hg/s). The muscarinic agonist acetylcholine (10 micrograms/kg IV) in the presence of… CONTINUE READING

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Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology • 2012

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