Physiological and Oncogenic Aurora-A Pathway

  title={Physiological and Oncogenic Aurora-A Pathway},
  author={Toshiaki Saeki and Mutsuko Ouchi and Toru 3 Ouchi},
  booktitle={International journal of biological sciences},
Aurora family of protein kinases have emerged as crucial factors of, not only mitosis and cytokinesis, but also human carcinogenesis. Among these family members is Aurora-A that is frequently overexpressed in varieties of human cancer. Both in vitro and in vivo studies demonstrated that Aurora-A induces tumorigenesis through genome instability. These studies have further shown that cell signaling cross-talk between Aurora-A and other cellular proteins are essential for fully-transformed… CONTINUE READING

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