Physiological actions of taurine.

@article{Huxtable1992PhysiologicalAO,
  title={Physiological actions of taurine.},
  author={Ryan J. Huxtable},
  journal={Physiological reviews},
  year={1992},
  volume={72 1},
  pages={
          101-63
        }
}
  • R. Huxtable
  • Published 1992
  • Biology, Medicine
  • Physiological reviews
Physiological role of taurine – from organism to organelle
TLDR
Taurine homeostasis in cells and organelles is described with emphasis on taurine biophysics/membrane dynamics, regulation of transport proteins involved in active and passive t aurine release as well as physiological processes, for example, development, lung function, mitochondrial function, antioxidative defence and apoptosis which seem to be affected by a shift in the expression of the taurin transporters and/or the cellular taurines. Expand
Long-term Feeding of the Yellowtail Seriola quinqueradiata with Soy Protein Concentrate-based Non-fishmeal Diet Supplemented with Taurine
Previous studies have shown that the growth performance of the yellowtail Seriola quinqueradiata fed non-fishmeal (non-FM) diets was improved by supplementing with dietary taurine. However, it hasExpand
The effect of taurine on dystrophic muscle tissue function
TLDR
The purpose of this thesis was to examine the effect of taurine on dystrophic skeletal muscle function, which was performed in three studies using the dyStrophic mdx mouse as a model for DMD. Expand
Parallel transcriptome evolution in stream threespine sticklebacks
TLDR
Divergence in the brain transcriptome between the ecotypes of Japanese and Canadian threespine sticklebacks shows parallelism and is mainly caused by genetic changes occurring on the same chromosome as the target genes. Expand
Special topic: The association between pulse ingredients and canine dilated cardiomyopathy: addressing the knowledge gaps before establishing causation1
TLDR
Dog food formulators should have a deep knowledge of processing methodologies and nutrient interactions beyond meeting the Association of American Feed Control Officials nutrient profiles and should not carelessly follow unsubstantiated market trends. Expand
Taurine and dopamine-related effects of ethanol. An experimental study in rodents
The reinforcing properties of alcohol (ethanol) are associated with activation of the mesolimbic dopamine system and the concomitant increase in dopamine in the nucleus accumbens (nAc). Changes inExpand
Metabolic assessment of a migraine model using relaxation‐enhanced 1H spectroscopy at ultrahigh field
TLDR
The high sensitivity and spectral dispersion available to 1H MRS at 21.1 T expands metabolic profiling in this migraine model to include lactate, taurine (Tau), aspartate, and Gly—a mixture of glycine, glutamine, and glutamate. Expand
Understanding taurine CNS activity using alternative zebrafish models
TLDR
The main physiological roles of taurine in mammals, including neuromodulation, osmoregulation, membrane stabilization, and antioxidant action are summarized, and recent advances in zebrafish drug screening are outlined. Expand
Oral and intravenous pharmacokinetics of taurine in sprague‐dawley rats: the influence of dose and the possible involvement of the proton‐coupled amino acid transporter, PAT1, in oral taurine absorption
TLDR
In vivo and in vitro results suggest that taurine absorption from the intestine is caused by PAT1, and the pharmacokinetic investigations showed that intestinal t aurine absorption was not saturable at the investigated doses, but that the time to reach the maximal plasma concentration increased with dose. Expand
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References

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Inotropic effect of taurine in guinea-pig ventricular strips.
TLDR
Taurine prevented the negative inotropic effect due to low calcium concentration in guinea-pig ventricular strips but not in rat strips and the presence of beta-alanine antagonized the effect of taurine suggesting that the action of t aurine was correlated to its transport. Expand
Adaptive regulation of taurine transport in two continuous renal epithelial cell lines.
TLDR
Taurine is transported by a beta-specific, Na-Cl dependent process in both renal epithelial cell lines, and an increased transport maximum is observed in cells which have been taurine-starved, and a decreased Jmax is seen in cells supplied with excess taurines. Expand
Amino acid content of epileptogenic human brain: focal versus
  • PhysioZogy, and Cardiology,
  • 1990
Effects of taurine depletion on intrinsic contractility of rat ventricular papillary muscles.
TLDR
It is suggested that taurine deficiency leads to reductions in action potential triggered calcium release from internal stores, and deficits in calcium sequestration, which may result from disfacilitation of calcium binding to the sarcoplasmic reticulum and other storage sites during taurin deficiency. Expand
Genetically ep:Hpsy-prone rats are ch bcterized by altered tissue trace elemarz, concentrations
  • Epilepsia 31:
  • 1990
Immunologic Consequences of Taurine Deficiency in Cats
Our results show that a lack of taurine in the diet of cats results in a significant leukopenia, a shift in the percentage of polymorphonuclear and mononuclear leukocytes, an increase in the absoluteExpand
L-cysteine, a bicarbonate-sensitive endogenous excitotoxin.
TLDR
L-cysteine is naturally present in the human brain and in the environment, and is much more powerful than beta-N-methylamino-L-alanine, a bicarbonate-dependent excitotoxin, which has been implicated in an adult neurodegenerative disorder endemic to Guam. Expand
SHAIN, AND R. MARTIN DEL RIO (Editors). Taurine: FunctionaL Neurochemistry, Physiology and Cardiology
  • 1990
Taurine concentrations in plasma and whole blood in humans: estimation of error from intra- and interindividual variation and sampling technique.
TLDR
Blood collection into EDTA-wetted plastic syringes at room temperature proved most reliable and whole-blood taurine would appear to be the best single measure for measuring plasma taurines. Expand
The effects of taurine on atherosclerosis development in cholesterol-fed rabbits.
TLDR
The possibility that taurine is reducing the development of atherosclerotic lesions through a mechanism involving its antioxidant activity is discussed, which appears to be unrelated to a fall in blood pressure. Expand
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