Physiological Sensing of Carbon Dioxide/Bicarbonate/pH via Cyclic Nucleotide Signaling

Abstract

Carbon dioxide (CO(2)) is produced by living organisms as a byproduct of metabolism. In physiological systems, CO(2) is unequivocally linked with bicarbonate (HCO(3)(-)) and pH via a ubiquitous family of carbonic anhydrases, and numerous biological processes are dependent upon a mechanism for sensing the level of CO(2), HCO(3), and/or pH. The discovery that… (More)
DOI: 10.3390/s110202112

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