Physiological Roles of Ubiquitin Ligases Related to the Endoplasmic Reticulum.

  title={Physiological Roles of Ubiquitin Ligases Related to the Endoplasmic Reticulum.},
  author={Masayuki Kaneko},
  journal={Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan},
  volume={136 6},
  • M. Kaneko
  • Published 2016
  • Biology
  • Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Studies on endoplasmic reticulum (ER)-associated degradation (ERAD), in which unfolded proteins accumulated in the ER are selectively transported to the cytosol for degradation by the ubiquitin-proteasome system, have been focused on molecular mechanisms in yeast. In human, disruption of the ER quality control system causes various diseases, such as neurodegenerative disease, lifestyle disease, and cancer. However, there are many ERAD genes with unknown physiological and pathological functions… 
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