Physiological Mechanisms Underlying Lactational Amenorrhea

@article{Mcneilly1994PhysiologicalMU,
  title={Physiological Mechanisms Underlying Lactational Amenorrhea},
  author={Alan S. Mcneilly and Clement C K Tay and Anna Glasier},
  journal={Annals of the New York Academy of Sciences},
  year={1994},
  volume={709}
}
Breastfeeding delays the resumption of normal ovarian cycles by disrupting the pattern of pulsatile release of GnRH from the hypothalamus and hence LH from the pituitary. The plasma concentrations of FSH during lactation are sufficient to induce follicle growth, but the inadequate pulsatile LH signal results in a reduced estradiol production by these follicles. When follicle growth and estradiol secretion does increase to normal, the suckling stimulus prevents the generation of a normal… Expand
Neuroendocrine changes and fertility in breast-feeding women.
  • A. Mcneilly
  • Biology, Medicine
  • Progress in brain research
  • 2001
TLDR
It is clear that breast-feeding in women can suppress fertility for prolonged periods, and women may proceed from pregnancy through lactation to another pregnancy and lactation with no menstrual period for several years. Expand
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TLDR
The data suggests that the failure to maintain ovarian follicular development post partum in breast feeding women may be due to a direct block of LH action at ovarian level, perhaps by the high levels of prolactin associated with lactation and an inability of the hypothalamic‐pituitary axis to maintain pulsatile secretion of LH in the face of the negative feedback effects of the increased oestrogen secretion resulting from the initiation of follicularDevelopment. Expand
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The pattern of pulsatile LH secretion in relation to that of follicle stimulating hormone (FSH) and prolactin, and suckling and ovarian activity at 4 and 8 weeks postpartum in 20 fully breastfeeding women with lactational amenorrhoea is determined. Expand
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TLDR
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TLDR
While follicular development occurred in all women, and evidence of luteinization was apparent in three out of four, normal ovulation and luteal function did not occur, suggesting that a simple disturbance in the pulsatile pattern of LHRH secretion may not be enough to explain the suppression of ovarian activity during lactation. Expand
THE ROLE OF PROLACTIN IN THE RESTORATION OF OVARIAN FUNCTION DURING THE EARLY POST‐PARTUM PERIOD IN THE HUMAN FEMALE
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