Physiological Levels of Nitric Oxide Diminish Mitochondrial Superoxide. Potential Role of Mitochondrial Dinitrosyl Iron Complexes and Nitrosothiols

Abstract

Mitochondria are the major source of superoxide radicals and superoxide overproduction contributes to cardiovascular diseases and metabolic disorders. Endothelial dysfunction and diminished nitric oxide levels are early steps in the development of these pathological conditions. It is known that physiological production of nitric oxide reduces oxidative… (More)
DOI: 10.3389/fphys.2017.00907

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@inproceedings{Dikalov2017PhysiologicalLO, title={Physiological Levels of Nitric Oxide Diminish Mitochondrial Superoxide. Potential Role of Mitochondrial Dinitrosyl Iron Complexes and Nitrosothiols}, author={Sergey I. Dikalov and V. I. Mayorov and Alexander V. Panov}, booktitle={Front. Physiol.}, year={2017} }