Physiological Indirect Effect Modeling of the Antilipolytic Effects of Adenosine A1-Receptor Agonists

@article{Schaick1997PhysiologicalIE,
  title={Physiological Indirect Effect Modeling of the Antilipolytic Effects of Adenosine A1-Receptor Agonists},
  author={Erno A. van Schaick and Henrik J. M. M. de Greef and Adriaan P. IJzerman and Meindert Danhof},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1997},
  volume={25},
  pages={673-694}
}
The relationship between blood concentrations of the adenosine A 1 -receptor agonist N6 -(p-sulfophenyI)adenosine (SPA) and its effect on both plasma nonesterified fatty acid (NEFA) and glycerol release was described on the basis of an integrated pharmacokinetic–pharmacodynamic model. An indirect response model rather than a hypothetical “link” model was used to account for the delayed response. For that purpose an empirical solution to the differential equation describing the physiological… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Pharmacokinetic-pharmacodynamic modelling of the anti-Iipolytic and anti-ketotic effects of the adenosine Arreceptor agonist N6-(p-sulfophenyl) adenosine in rats

  • E. A. van Schaick, H.J.M.M. de Greef, M.W.E. Langemeijer, M. J. Sheehan, A. P. IJzerman, M. Danhof
  • Br. J. Pharmacol. 122:525-533,
  • 1997
Highly Influential
4 Excerpts

Rationale for activation of adenosine A, receptors in adipocytes in the treatment of non-insulin dependent diabetes mellitus

  • J. E. Foley
  • Drug. Deo. Res
  • 1994
Highly Influential
4 Excerpts

Partial agonists at the adenosine A, receptor in vivo

  • R.A.A. Mathot, E. M. van der Wenden, W. Soudijn, A. P. IJzerman, M. Danhof. Deoxyribose analogues of N6-cyclopentylade CPA
  • Br. J. Pharmacol. 116:1957-1964
  • 1995
2 Excerpts

Similar Papers

Loading similar papers…