Physiological Indirect Effect Modeling of the Antilipolytic Effects of Adenosine A1-Receptor Agonists

  title={Physiological Indirect Effect Modeling of the Antilipolytic Effects of Adenosine A1-Receptor Agonists},
  author={Erno A. van Schaick and Henrik J. M. M. de Greef and Adriaan P. IJzerman and Meindert Danhof},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
The relationship between blood concentrations of the adenosine A 1 -receptor agonist N6 -(p-sulfophenyI)adenosine (SPA) and its effect on both plasma nonesterified fatty acid (NEFA) and glycerol release was described on the basis of an integrated pharmacokinetic–pharmacodynamic model. An indirect response model rather than a hypothetical “link” model was used to account for the delayed response. For that purpose an empirical solution to the differential equation describing the physiological… CONTINUE READING


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