Physiological/pathological ramifications of transcription factors in the unfolded protein response.

@article{Han2017PhysiologicalpathologicalRO,
  title={Physiological/pathological ramifications of transcription factors in the unfolded protein response.},
  author={Jaeseok Han and Randal J Kaufman},
  journal={Genes & development},
  year={2017},
  volume={31 14},
  pages={1417-1438}
}
Numerous environmental, physiological, and pathological insults disrupt protein-folding homeostasis in the endoplasmic reticulum (ER), referred to as ER stress. Eukaryotic cells evolved a set of intracellular signaling pathways, collectively termed the unfolded protein response (UPR), to maintain a productive ER protein-folding environment through reprogramming gene transcription and mRNA translation. The UPR is largely dependent on transcription factors (TFs) that modulate expression of genes… CONTINUE READING

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