Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors

@article{Sarin2009PhysiologicUL,
  title={Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors},
  author={Hemant Sarin and Ariel S Kanevsky and Haitao Wu and Alioscka A. Sousa and Colin M. Wilson and Maria A. Aronova and Gary L. Griffiths and Richard Leapman and H. Vo},
  journal={Journal of Translational Medicine},
  year={2009},
  volume={7},
  pages={51 - 51}
}
The existence of large pores in the blood-tumor barrier (BTB) of malignant solid tumor microvasculature makes the blood-tumor barrier more permeable to macromolecules than the endothelial barrier of most normal tissue microvasculature. The BTB of malignant solid tumors growing outside the brain, in peripheral tissues, is more permeable than that of similar tumors growing inside the brain. This has been previously attributed to the larger anatomic sizes of the pores within the BTB of peripheral… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

Imaging Gliomas with Nanoparticle-Labeled Stem Cells

Chinese medical journal • 2018
View 8 Excerpts
Highly Influenced

Nano-sized drug carriers: Extravasation, intratumoral distribution, and their modeling.

Journal of controlled release : official journal of the Controlled Release Society • 2017

Perspectives on Dual Targeting Delivery Systems for Brain Tumors

Journal of Neuroimmune Pharmacology • 2016
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.

Proceedings of the National Academy of Sciences of the United States of America • 1998
View 7 Excerpts
Highly Influenced

Visualization of dendrimer molecules by transmission electron microscopy (TEM): Staining methods and cryoTEM of vitrified solutions

CL Jackson, HD Chanzy, +4 authors EJ Amis
Macromolecules • 1998
View 8 Excerpts
Highly Influenced

Openings between defective endothelial cells explain tumor vessel leakiness.

The American journal of pathology • 2000
View 5 Excerpts
Highly Influenced

Renal clearance of quantum dots

Nature Biotechnology • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…