Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors

  title={Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors},
  author={Hemant Sarin and Ariel S Kanevsky and Haitao Wu and Alioscka A. Sousa and Colin M. Wilson and Maria A. Aronova and Gary L. Griffiths and Richard Leapman and H. Vo},
  journal={Journal of Translational Medicine},
  pages={51 - 51}
The existence of large pores in the blood-tumor barrier (BTB) of malignant solid tumor microvasculature makes the blood-tumor barrier more permeable to macromolecules than the endothelial barrier of most normal tissue microvasculature. The BTB of malignant solid tumors growing outside the brain, in peripheral tissues, is more permeable than that of similar tumors growing inside the brain. This has been previously attributed to the larger anatomic sizes of the pores within the BTB of peripheral… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 43 references

Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.

Proceedings of the National Academy of Sciences of the United States of America • 1998
View 7 Excerpts
Highly Influenced

Visualization of dendrimer molecules by transmission electron microscopy (TEM): Staining methods and cryoTEM of vitrified solutions

CL Jackson, HD Chanzy, +4 authors EJ Amis
Macromolecules • 1998
View 8 Excerpts
Highly Influenced

Openings between defective endothelial cells explain tumor vessel leakiness.

The American journal of pathology • 2000
View 5 Excerpts
Highly Influenced

Renal clearance of quantum dots

Nature Biotechnology • 2007
View 1 Excerpt

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