Physiologic role for "inducible" nitric oxide synthase: a new form of astrocytic-neuronal interface.

@article{Amitai2010PhysiologicRF,
  title={Physiologic role for "inducible" nitric oxide synthase: a new form of astrocytic-neuronal interface.},
  author={Yael Amitai},
  journal={Glia},
  year={2010},
  volume={58 15},
  pages={1775-81}
}
Nitric oxide (NO) has been long recognized as an atypical neuronal messenger affecting excitatory synaptic transmission, but its cellular source has remained unresolved as the neuronal isoform of NO synthase (nNOS) in many brain regions is expressed only by small subsets of inhibitory neurons. It is generally believed that the glial NO-producing isoform (iNOS) is not expressed in the normal brain, but rather it undergoes a transcription-mediated up-regulation following an immunological… CONTINUE READING

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