Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D by phosphorus in normal men.

@article{Portale1989PhysiologicRO,
  title={Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D by phosphorus in normal men.},
  author={Anthony A Portale and Bernard P. Halloran and Robert C. Morris},
  journal={The Journal of clinical investigation},
  year={1989},
  volume={83 5},
  pages={
          1494-9
        }
}
We asked this question: in normal humans, is either a normal dietary intake or normal serum concentration of phosphorus a determinant of the serum concentration of 1,25(OH)2D? In seven normal men whose dietary phosphorus was decreased from 2,300 to 625 mg/d, each intake for 8-9 d, under strictly controlled, normal metabolic conditions, we measured serum concentrations of 1,25(OH)2D daily, and concentrations of phosphorus hourly throughout a 24-h period, before and after restriction. Decreasing… Expand

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