Physiologic regulation of atrial natriuretic peptide receptors in rat renal glomeruli.

@article{Ballermann1985PhysiologicRO,
  title={Physiologic regulation of atrial natriuretic peptide receptors in rat renal glomeruli.},
  author={Barbara J Ballermann and Richard L Hoover and Morris J. Karnovsky and Barry M. Brenner},
  journal={The Journal of clinical investigation},
  year={1985},
  volume={76 6},
  pages={2049-56}
}
Isolated rat renal glomeruli and cultured glomerular mesangial and epithelial cells were examined for atrial natriuretic peptide (ANP) receptors, and for ANP-stimulated cyclic guanosine monophosphate (cGMP) generation. In glomeruli from normal rats, human (1-28) 125I-ANP bound to a single population of high affinity receptors with a mean equilibrium dissociation constant of 0.46 nM. Human (1-28) ANP markedly stimulated cGMP generation, but not cAMP generation in normal rat glomeruli. Analogues… CONTINUE READING
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