Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell loss after traumatic brain injury in female rats.

@article{Robertson2006PhysiologicPR,
  title={Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell loss after traumatic brain injury in female rats.},
  author={Courtney L. Robertson and April Puskar and Gloria E. Hoffman and Anne Z Murphy and Manda Saraswati and Gary Fiskum},
  journal={Experimental neurology},
  year={2006},
  volume={197 1},
  pages={235-43}
}
Growing literature suggests important sex-based differences in outcome following traumatic brain injury (TBI) in animals and humans. Progesterone has emerged as a key hormone involved in many potential neuroprotective pathways after acute brain injury and may be responsible for some of these differences. Many studies have utilized supraphysiologic levels of post-traumatic progesterone to reverse pathologic processes after TBI, but few studies have focused on the role of endogenous physiologic… CONTINUE READING
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