Physiologic indirect response models characterize diverse types of pharmacodynamic effects.

@article{Jusko1994PhysiologicIR,
  title={Physiologic indirect response models characterize diverse types of pharmacodynamic effects.},
  author={William J. Jusko and Hui C. Ko},
  journal={Clinical pharmacology and therapeutics},
  year={1994},
  volume={56 4},
  pages={406-19}
}
A family of four basic physiologic indirect response models has been proposed to account for the pharmacodynamics of drugs that act by way of inhibition or stimulation of the production or loss of endogenous substances or mediators. Such models were applied previously to account for the anticoagulant effects of warfarin, adrenal suppression by corticosteroids, cell trafficking effects of corticosteroids, antipyretic effects of ibuprofen, and aldose reductase inhibition. Additional responses… CONTINUE READING

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