Physiologic doses of depot-medroxyprogesterone acetate do not increase acute plasma simian HIV viremia or mucosal virus shedding in pigtail macaques.

@article{Radzio2014PhysiologicDO,
  title={Physiologic doses of depot-medroxyprogesterone acetate do not increase acute plasma simian HIV viremia or mucosal virus shedding in pigtail macaques.},
  author={Jessica Radzio and Krisztina Z Hanley and James Mitchell and Shanon Ellis and Frank Deyounks and Leecresia T. Jenkins and Debra L. Hanson and Walid Heneine and Jos{\'e} Gerardo Garc{\'i}a-Lerma},
  journal={AIDS},
  year={2014},
  volume={28 10},
  pages={1431-9}
}
OBJECTIVE Epidemiologic studies remain inconclusive on whether the injectable contraceptive depot-medroxyprogesterone acetate (DMPA) increases mucosal HIV shedding and transmissibility. Nonhuman primate models may help to determine the effects of DMPA on acute HIV replication. DESIGN We defined a physiologic dose of DMPA in macaques and assessed the impact of DMPA on acute simian HIV (SHIV) replication. METHODS Pigtail macaques received 1-30  mg of DMPA intramuscularly followed by… CONTINUE READING
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