Physiologic changes in pregnancy and their effect on drug disposition.

  title={Physiologic changes in pregnancy and their effect on drug disposition.},
  author={Marilynn C. Frederiksen},
  journal={Seminars in perinatology},
  volume={25 3},
Changes in maternal physiology occur normally during pregnancy and have the potential to alter the absorption, distribution, and elimination of drugs used therapeutically in pregnant women. These physiologic changes include: plasma volume expansion and increases in extracellular fluid space and total body water; decreased plasma albumin concentration; a compensated respiratory alkalosis; increased cardiac output with regional blood flow changes; increased renal blood flow associated with… CONTINUE READING


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