Physiologic and molecular characterization of a murine model of right ventricular volume overload.

Abstract

Pulmonary insufficiency (PI) is a common long-term sequel after repair of tetralogy of Fallot, causing progressive right ventricular (RV) dilation and failure. We describe the physiologic and molecular characteristics of the first murine model of RV volume overload. PI was created by entrapping the pulmonary valve leaflets with sutures. Imaging… (More)
DOI: 10.1152/ajpheart.00776.2012

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