Physiologic and Molecular Determinants of Insulin Action In the Baboon

Abstract

Objective: To quantitate insulin sensitivity in lean and obese non-diabetic baboons and examine the underlying cellular/molecular mechanisms responsible for impaired insulin action in order to characterize a baboon model of insulin resistance. Material/Methods: 20 baboons received a hyperinsulinemic euglycemic clamp, with skeletal muscle and visceral… (More)

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