Physiologic alteration of fibrinogen levels: influence upon patency of microvenous anastomoses.

@article{Cooley1992PhysiologicAO,
  title={Physiologic alteration of fibrinogen levels: influence upon patency of microvenous anastomoses.},
  author={Brian Cooley and J. D. Fowler and John S Gould},
  journal={Microsurgery},
  year={1992},
  volume={13 6},
  pages={299-303}
}
High baseline levels of plasma fibrinogen have been correlated with increased risk for cardiovascular disease. Since fibrinogen plays a central role in both coagulation and platelet aggregation and is a primary component of thrombi, this study was designed to assess the relationship of circulating fibrinogen concentration and vein anastomotic patency. Subcutaneously injected turpentine was used to increase, and intravenous ancrod (snake venom) to decrease, plasma fibrinogen levels. Rat femoral… CONTINUE READING
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