Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4+ T Cells.

Abstract

Immune aging may underlie various aging-related disorders, including diminished resistance to infection, chronic inflammatory disorders, and autoimmunity. PD-1+ and CD153+ CD44high CD4+ T cells with features of cellular senescence, termed senescence-associated T (SA-T) cells, increasingly accumulate with age and may play a role in the immune aging phenotype… (More)
DOI: 10.4049/jimmunol.1602005

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@article{Sato2017PhysiologicTI, title={Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4+ T Cells.}, author={Kyosuke Sato and Aiko Kato and Miho Sekai and Yoko Hamazaki and Nagahiro Minato}, journal={Journal of immunology}, year={2017}, volume={199 1}, pages={138-148} }