Physiologic Diversity and Development of Intrinsically Photosensitive Retinal Ganglion Cells

@article{Tu2005PhysiologicDA,
  title={Physiologic Diversity and Development of Intrinsically Photosensitive Retinal Ganglion Cells},
  author={Daniel C. Tu and Dongyang Zhang and Jay Demas and Elon B. Slutsky and Ignacio Provencio and Timothy E. Holy and Russell N. Van Gelder},
  journal={Neuron},
  year={2005},
  volume={48},
  pages={987-999}
}
Intrinsically photosensitive retinal ganglion cells (ipRGCs) mediate numerous nonvisual phenomena, including entrainment of the circadian clock to light-dark cycles, pupillary light responsiveness, and light-regulated hormone release. We have applied multielectrode array recording to characterize murine ipRGCs. We find that all ipRGC photosensitivity is melanopsin dependent. At least three populations of ipRGCs are present in the postnatal day 8 (P8) murine retina: slow onset, sensitive, fast… CONTINUE READING
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