Physics of adherent cells

@article{Schwarz2013PhysicsOA,
  title={Physics of adherent cells},
  author={Ulrich S. Schwarz and Shmuel Safran},
  journal={Reviews of Modern Physics},
  year={2013},
  volume={85},
  pages={1327-1381}
}
properties of cells and their physical environment. Here we review recent progress in our understanding of the role of forces in cell adhesion from the viewpoint of theoretical soft matter physics and in close relation to the relevant experiments. 

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References

SHOWING 1-10 OF 608 REFERENCES

Soft matters in cell adhesion: rigidity sensing on soft elastic substrates.

TLDR
The physical scales of living cells which follow from simple scaling arguments developed in soft matter physics are discussed and the way cells sense and react to extracellular stiffness as revealed by recent experiments with soft elastic substrates is discussed.

Effect of poisson ratio on cellular structure formation.

TLDR
This work shows analytically that due to screening, the effective interaction between strings decays exponentially, with a decay length determined only by geometry, and predicts novel phase transitions from paraelastic to ferroelastic and antiferroelastics phases as a function of the Poisson ratio.

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

TLDR
It is demonstrated that micropost rigidity impacts cell morphology, focal adhesions, cytoskeletal contractility and stem cell differentiation, and early changes in cytoskeleton contractility predicted later stem cell fate decisions in single cells.

Rigidity sensing explained by active matter theory.

Theoretical concepts and models of cellular mechanosensing.

Physical determinants of cell organization in soft media.

Dissipative interactions in cell–matrix adhesion

TLDR
There is a need to overcome this imbalance and to reveal the impact of dissipative processes in cell–matrix interaction, which is currently heavily addressed in biophysical and biomaterials science.

Dynamics and morphology of microvilli driven by actin polymerization.

  • N. Gov
  • Biology
    Physical review letters
  • 2006
TLDR
This work model these structures as arising from the balance between the force of actin polymerization and the restoring force of the membrane and describes the phase diagram and the resulting morphology of the microvilli aggregates on the cell surface.

Optical rheology of biological cells.

TLDR
The symmetric geometry of suspended cells ensures minimal statistical variability in their viscoelastic properties in contrast with adherent cells and thus is defining for different cell types.

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

TLDR
The molecular mechanisms by which forces might act at a distance to induce mechanochemical conversion in the nucleus and alter gene activities are explored.
...