Physicochemical properties of low molecular weight alkylated chitosans: a new class of potential nonviral vectors for gene delivery.

Low molecular weight chitosans grafted with N-/2(3)-(dodec-2-enyl)succinoyl groups (HM-LMW-chitosans) with a mean molecular mass of 5 kDa, a degree of acetylation of 3% and a degree of tetradecenoyl substitution (TDC) of 3-18 mol% have been synthesized. These molecules are monodisperse and soluble in water at neutral pH. Using tensiometry and Nile Red… CONTINUE READING