Physicochemical properties of T-cell-activating monokines in guinea pigs.


T-cell-activating monokines of guinea pigs with interleukin 1-like activity were produced in protein-free medium by stimulation of peritoneal macrophages with synthetic muramyl dipeptide (MDP). Gel filtration of the culture supernatant of MDP-stimulated macrophages revealed that most of the activity to potentiate the responses of thymocytes and lymph node T… (More)


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