Physicochemical properties and anti-opisthorchosis effect of mechanochemically synthesized supramolecular complexes of Albendazole with the polysaccharide Arabinogalactan from Larix sibirica and Larix gmelinii

Abstract

212 Opisthorchosis provoked by trematodes Opisthorchis felineus is one of the most widely spread helminthiasis in Russia, which affects at least 50–80% of the population of Western Siberia [1]. In the past decades, opisthorchosis has been treated with large action spectrum drugs, such as Praziquantel and Albendazole (ABZ). One of significant disadvantages of these preparations is their high toxicity [2]. More over, risks of teratogenic and carcinogenic effects of these preparations should also be taken into account. Praziquantel exhibited positive effects upon treatment of acute opisthorchosis, though it was not sufficiently effective in cases of most widely spread chronic opisthorchosis. Therefore, the development of novel antihelminthic agents and/or increase in efficiency of the existing ones is considered to be a challenging problem.

DOI: 10.1134/S0012496614030156

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@article{Chistyachenko2014PhysicochemicalPA, title={Physicochemical properties and anti-opisthorchosis effect of mechanochemically synthesized supramolecular complexes of Albendazole with the polysaccharide Arabinogalactan from Larix sibirica and Larix gmelinii}, author={Yu. S. Chistyachenko and Mikhail Khvostov and A. I. Belousov and Nadezhda A. Zhukova and M. Yu. Pakharukova and Aleksey V. Katokhin and Salavat S Khalikov and Tatjana G. Tolstikova and Alexander V. Dushkin and Viatcheslav A. Mordvinov and Nikolay Z Lyakhov}, journal={Doklady Biological Sciences}, year={2014}, volume={456}, pages={212-214} }