- V A Mordvinov, N I Yurlova, L M Ogorodova, A V Katokhin
- Parasitol. Int
212 Opisthorchosis provoked by trematodes Opisthorchis felineus is one of the most widely spread helminthiasis in Russia, which affects at least 50–80% of the population of Western Siberia . In the past decades, opisthorchosis has been treated with large action spectrum drugs, such as Praziquantel and Albendazole (ABZ). One of significant disadvantages of these preparations is their high toxicity . More over, risks of teratogenic and carcinogenic effects of these preparations should also be taken into account. Praziquantel exhibited positive effects upon treatment of acute opisthorchosis, though it was not sufficiently effective in cases of most widely spread chronic opisthorchosis. Therefore, the development of novel antihelminthic agents and/or increase in efficiency of the existing ones is considered to be a challenging problem.