Physicochemical perspectives on the cariostatic mechanisms of systemic and topical fluorides.

@article{Margolis1990PhysicochemicalPO,
  title={Physicochemical perspectives on the cariostatic mechanisms of systemic and topical fluorides.},
  author={Henry C. Margolis and Erika Carmona Moreno},
  journal={Journal of dental research},
  year={1990},
  volume={69 Spec No},
  pages={
          606-13; discussion 634-6
        }
}
The cariostatic mechanisms of systemic and topical fluoride agents are considered in light of a previously proposed model for the caries process. It is noted that fluoride, in principle, can induce a cariostatic effect: by (1) reducing enamel solubility when incorporated into the mineral structure; (2) by fostering the remineralization of incipient enamel lesions and the deposition of fluoridated phases (within dental plaque) which provide a source of mineral ions (Ca, P, F) under acidic… CONTINUE READING
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