Physicochemical parameters of non-viral vectors that govern transfection efficiency.

  title={Physicochemical parameters of non-viral vectors that govern transfection efficiency.},
  author={Beno{\^i}t Barteau and Rapha{\"e}l Ch{\`e}vre and Emilie Letrou-Bonneval and Romain Labas and Olivier Lambert and Bruno Pitard},
  journal={Current gene therapy},
  volume={8 5},
Gene therapy is based on the vectorization of nucleic acids to target cells and their subsequent expression. Cationic lipids and polymers are the most widely used vectors for the delivery of DNA into cultured cells. Nowadays, numerous reagents made of these cationic molecules are commercially available and used by researchers from the academic and industrial field. By contrast their evaluations in preclinical programs have revealed that their use for in vivo applications will be more… CONTINUE READING

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