Physicochemical interpretation of the pharmacokinetics of percutaneous absorption

  title={Physicochemical interpretation of the pharmacokinetics of percutaneous absorption},
  author={Richard Guy and Jonathan Hadgraft},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
Theoretical expressions are derived to predict the amount of a drug reaching the dermal capillaries as a function of simple physicochemical parameters. The mathematical approach involves the solution of the diffusion equation for the drug in the skin using the technique of Laplace transformation. Firstorder kinetics are assumed for the absorption of drug from the vehicle into the skin and for uptake into the capillaries. The relative importance of these different processes (absorption from… CONTINUE READING