Physicochemical determinants in the cellular responses to nanostructured amorphous silicas.

@article{Gazzano2012PhysicochemicalDI,
  title={Physicochemical determinants in the cellular responses to nanostructured amorphous silicas.},
  author={Elena Gazzano and Mara Ghiazza and Manuela Polimeni and Vera Bolis and Ivana Fenoglio and Angelo Attanasio and Gianna Mazzucco and Bice Fubini and Dario Ghigo},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2012},
  volume={128 1},
  pages={158-70}
}
Amorphous silicas, opposite to crystalline polymorphs, have been regarded so far as nonpathogenic, but few studies have addressed the toxicity of the wide array of amorphous silica forms. With the advent of nanotoxicology, there has been a rising concern about the safety of silica nanoparticles to be used in nanomedicine. Here, we report a study on the toxicity of amorphous nanostructured silicas obtained with two different preparation procedures (pyrolysis vs. precipitation), the pyrogenic in… CONTINUE READING