Physicochemical considerations in the preparation of amorphous ritonavir-poly(ethylene glycol) 8000 solid dispersions.

@article{Law2001PhysicochemicalCI,
  title={Physicochemical considerations in the preparation of amorphous ritonavir-poly(ethylene glycol) 8000 solid dispersions.},
  author={Devalina Law and Steven L. Krill and Eric A. Schmitt and James J Fort and Yihong Qiu and Weili Wang and William R. Porter},
  journal={Journal of pharmaceutical sciences},
  year={2001},
  volume={90 8},
  pages={1015-25}
}
A systematic study of the properties of ritonavir and the influence of polyethylene glycol 8000 (PEG) on ritonavir revealed that amorphous ritonavir dispersions in PEG would have an improved dissolution profile and could exhibit long-term stability. Ritonavir, a human immunodeficiency virus (HIV) protease inhibitor, is highly lipophilic [distribution coefficient (log D)= 4.3, 25 degrees C, pH 6.8], poorly water soluble (400 microg/mL in 0.1 N HCl, 1 microg/mL at pH 6.8, 37 degrees C), and… CONTINUE READING
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