Physicochemical characterizations of piroxicam-poloxamer solid dispersion.

  title={Physicochemical characterizations of piroxicam-poloxamer solid dispersion.},
  author={Sang Chul Shin and C W Cho},
  journal={Pharmaceutical development and technology},
  volume={2 4},
To develop an efficient topical delivery system for piroxicam using poloxamer gel formulation, physicochemical behavior of piroxicam in poloxamer was studied. The gelling property of poloxamer and the solubility of piroxicam in the poloxamer were investigated. The interaction between piroxicam and poloxamer was studied by x-ray diffractometry (XRD), infrared (IR) spectroscopy and differential thermal analysis (DTA) with a solid dispersion, coprecipitate, or physical mixture. Poloxamer 407… CONTINUE READING