Physicochemical characterization of solid lipid nanoparticles (SLNs) prepared by a novel microemulsion technique.

@article{Shah2014PhysicochemicalCO,
  title={Physicochemical characterization of solid lipid nanoparticles (SLNs) prepared by a novel microemulsion technique.},
  author={Rohan M. Shah and François Malherbe and Daniel S Eldridge and Enzo A. Palombo and Ian H. Harding},
  journal={Journal of colloid and interface science},
  year={2014},
  volume={428},
  pages={
          286-94
        }
}

• Rohan M. Shah, François Malherbe, +2 authors Ian H. Harding
• Published in Journal of colloid and interface science 2014
• DOI:10.1016/j.jcis.2014.04.057

HYPOTHESIS Solid lipid nanoparticles (SLNs) produced by conventional microemulsion techniques using thermal heat have specific limitations (e.g. high polydispersity, instability and low encapsulation). Replacing thermal heat with microwave heat may produce SLNs which overcome some of these limitations. EXPERIMENTS Stearic acid-based SLNs prepared with Tween® 20 as the emulsifier were chosen as the optimum formulation to encapsulate and potentially deliver the antibacterial drug tetracycline… CONTINUE READING

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