Physicochemical characterization of nedocromil bivalent metal salt hydrates. 3. Nedocromil calcium.

  title={Physicochemical characterization of nedocromil bivalent metal salt hydrates. 3. Nedocromil calcium.},
  author={H. Zhu and J. A. Halfen and V. Young and B. Padden and E. Munson and V. Menon and D. J. Grant},
  journal={Journal of pharmaceutical sciences},
  volume={86 12},
  • H. Zhu, J. A. Halfen, +4 authors D. J. Grant
  • Published 1997
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • A crystalline pentahydrate and a crystalline 8/3 hydrate of nedocromil calcium (NC) were prepared. The relationships between these solid phases and the nature of the water interactions in their structures were studied through characterization by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Karl Fischer titrimetry (KFT), hot-stage microscopy (HSM), ambient- or variable-temperature powder X-ray diffraction (PXRD), Fourier-transform infrared (FTIR) spectroscopy, solid… CONTINUE READING
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