Physicochemical characterization and stability of rifampicin liposome dry powder formulations for inhalation.

  title={Physicochemical characterization and stability of rifampicin liposome dry powder formulations for inhalation.},
  author={Narumon Changsan and Hak-Kim Chan and Frances Separovic and Teerapol Srichana},
  journal={Journal of pharmaceutical sciences},
  volume={98 2},
Liposomes were used to encapsulate rifampicin (RIF) as an alternative formulation for delivery to the respiratory tract. Factors affecting the stability of liposomes containing RIF were determined. Four liposome suspensions were prepared, containing different millimole ratios of cholesterol (CH) and soybean L-infinity-phosphatidylcholine (SPC) by the chloroform film method, followed by freeze-drying. Cryo-transmission electron microscopy, photon correlation spectroscopy, (2)H and (31)P solid… 

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