Physicochemical characterization and dissolution of norfloxacin/cyclodextrin inclusion compounds and PEG solid dispersions

  title={Physicochemical characterization and dissolution of norfloxacin/cyclodextrin inclusion compounds and PEG solid dispersions},
  author={Mich{\`e}le Guyot and Fawaz Fawaz and Jacques Bildet and François Bonini and A. M. Lagueny},
  journal={International Journal of Pharmaceutics},
Abstract Increase in the poor water solubility and dissolution rate of norfloxacin was studied. Two systems were used: solid dispersion with PEG 6000 prepared using the fusion method and inclusion complexes with cyclodextrins (β-cyclodextrin and HP-β-cyclodextrin) obtained by freeze-drying. IR spectrophotometry, X-ray diffractometry, and differential scanning calorimetry showed differences between norfloxacin/cyclodextrin complexes and their corresponding physical mixtures, but not between… Expand
Bioavailability of norfloxacin from PEG 6000 solid dispersion and cyclodextrin inclusion complexes in rabbits
Abstract A comparative bioavailability study was carried out in rabbits on pure powder of norfloxacin and its formulations: aqueous solution, polyethyleneglycol 6000 solid dispersions (PEG 6000 SD),Expand
Preparation and characterization of Domperidone- β-cyclodextrin complexes prepared by kneading method
Enhancement of the solubility and dissolution of domperidone using dispersion complex with β-cyclodextrin and hydroxy propyl cellulose by kneading technique. The physical mixtures (PM) of drug withExpand
Hydrophilic polymer solubilization on norfloxacin solubility in preparation of solid dispersion
Abstract The effects of single and binary hydrophilic polymers on the solubility and dissolution parameters of a poorly water-soluble drug, norfloxacin, via solid dispersions using the solventExpand
Effect of Norfloxacin Complexation with β-Cyclodextrin on the in Vitro Dissolution Behaviour and its Interaction with Mg2+ and Al3+
Interaction between norfloxacin and β-cyclodextrin (β-CD) in solution was characterized by immersion calorimetry studies and nuclear magnetic resonance. 1H-NMR studies suggest that the pyperazineExpand
Physicochemical characterization and in vitro dissolution behaviour of celecoxib-β-cyclodextrin inclusion complexes
Dissolution rate of the complexes was significantly greater than that of the corresponding physical mixtures and pure drug, indicating that the formation of inclusion complex increased the solubility of the poorly soluble drug celecoxib. Expand
Preparation, characterization and in vitro dissolution studies of solid dispersion of meloxicam with PEG 6000.
The solid dispersions of the drug demonstrated higher drug dissolution rates than physical mixtures and pure meloxicam, as a result of increased wettability and dispersibility of drug in a solid dispersion system. Expand
Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
The thermal analysis and microbiological studies showed that the thermal stability of the drug is enhanced in the presence of β-cyclodextrin and the complexes have better potency when compared with pure drug. Expand
Preparation, physicochemical characterization and dissolution studies of etoricoxib-β-cyclodextrin complexes
The aim of this work was to evaluate the role of β-cyclodextrin (β-CD), a cyclic oligosaccharide, in solubility and dissolution enhancement of poorly water-soluble etoricoxib (ETC), a specificExpand
Etodolac and solid dispersion with β-cyclodextrin
AbstractEtodolac/β-cyclodextrin (Eto/β-CD) dispersions were prepared with a view to study the influence of β-CD on the solubility and dissolution rate of this poorly soluble drug. Two systems wereExpand
Complexation of celecoxib with β‐cyclodextrin: Characterization of the interaction in solution and in solid state
Inclusion complexation between celecoxib, a specific cyclooxygenase II inhibitor, and beta-cyclodextrin (beta-CD) was studied in solution and solid state. Drug cyclodextrin complexes were prepared byExpand


Comparison of tolbutamide β-cyclodextrin inclusion compounds and solid dispersions: Physicochemical characteristics and dissolution studies
Abstract Tolbutamide was found to form an inclusion complex with β-cyclodextrin. An equilibrium phase solubility diagram was obtained for the tolbutamide-β-cyclodextrin system in water. TheExpand
Indomethacin and cyclodextrin complexes
Abstract Different complexes of indomethacin and both β-cyclodextrin (βCD) and hydroxypropyl jS-cyclodextrin (HPβCD) were prepared using different methods: kneading, spray-drying and neutralizationExpand
Characterization and dissolution of fenofibrate solid dispersion systems
Abstract In this study, solid dispersion systems of the sparingly water soluble drug, fenofibrate, in PEG 6000 and PVP were prepared and characterized. The effect of particle size of solidExpand
A study of the inclusion complex of naproxen with β-cyclodextrin
The aim of this study was to increase the solubility and dissolution rate of naproxen (NAP) by inclusion complex formation with β-cyclodextrin (β-CD). The solubility of NAP with β-CD in aqueousExpand
An investigation into the mechanisms of dissolution of alkyl p-aminobenzoates from polyethylene glycol solid dispersions
Abstract The solubility, melting and dissolution behaviour of methyl, ethyl, propyl and butyl p-aminobenzoates (PABAs) have been studied, both alone and as dispersions in polyethylene glycol (PEG)Expand
Solid particulates of drug-β-cyclodextrin inclusion complexes directly prepared by a spray-drying technique
Abstract Inclusion complexes of drugs (acetaminophen, indomethacin, piroxicam and warfarin) with β-cyclodextrin were experimentally prepared by using a spray-drying technique. The spray-driedExpand
Cyclodextrins in drug carrier systems.
  • K. Uekama, M. Otagiri
  • Chemistry, Medicine
  • Critical reviews in therapeutic drug carrier systems
  • 1987
The works published thus far apparently indicate that the inclusion phenomena of cyclodextrin analogs may allow the rational design of drug formulation and that the combination of molecular encapsulation with other carrier systems will become a very effective and valuable method for the development of a new drug delivery system in the near future. Expand
Crystallinity and dissolution rate of tolbutamide solid dispersions prepared by the melt method.
The X-ray patterns of rapid- and slow-cooled dispersions of tolbutamide and polyethylene glycol 6000 demonstrated that a physical mixture of drug and carrier resulted from both methods of dispersion preparation. Expand
Study of the interaction of clobazam with cyclodextrins in solution and in the solid state.
It was observed that DM-beta-CyD had the highest stability constant among the four CyDs in solution and clobazam molecules existed in a molecularly dispersed state in the ground mixture of CyDs. Expand
Development of aqueous parenteral formulations for carbamazepine through the use of modified cyclodextrins.
The onset of anticonvulsant action was rapid and consistent with almost instantaneous in vivo complex dissociation, and the low toxicity of 2-hydroxypropyl-beta-cyclodextrin and its ability to enhance the aqueous solubility of carbamazipine highly favor the use of this excipient. Expand