Physicochemical characterization, in vitro, and in vivo evaluation of indomethacin-loaded nanocarriers self-assembled by amphiphilic polyphosphazene.

@article{Zhang2008PhysicochemicalCI,
  title={Physicochemical characterization, in vitro, and in vivo evaluation of indomethacin-loaded nanocarriers self-assembled by amphiphilic polyphosphazene.},
  author={Jian Zhang and Shu Hui Li and Xiao Hui Li and Li Yan Qiu and Xiao Dong Li and Xiao Jing Li and Yi Jin and Kang Jie Zhu},
  journal={Journal of biomedical materials research. Part A},
  year={2008},
  volume={86 4},
  pages={914-25}
}
Copolymeric nanocarriers assembled by amphiphilic polyphosphazene bearing poly(N-isopropylacrylamide) (PNIPAAm) and ethyl glycinate (EtGly) as substitutes, were investigated as drug vehicles for indomethacin (IND). The physicochemical characteristics of the novel nanocontainers were studied, including lower critical solution temperature (LCST), critical micelle concentration (CMC) and drug loading capacity. LCST measurements revealed that copolymer is more sensitive to the introduction of salts… CONTINUE READING
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