Physicochemical characteristics of soluble oligomeric Aβ and their pathologic role in Alzheimer's disease

@article{Watson2005PhysicochemicalCO,
  title={Physicochemical characteristics of soluble oligomeric A$\beta$ and their pathologic role in Alzheimer's disease},
  author={Desiree Watson and Eduardo Miguel Casta{\~n}o and Tyler A. Kokjohn and Yu-Min Kuo and Yuri L. Lyubchenko and David J Pinsky and E. Sander Connolly and Chera L. Esh and Dean C. Luehrs and William B. Stine and L. Rowse and Mark R. Emmerling and Alex E. Roher},
  journal={Neurological Research},
  year={2005},
  volume={27},
  pages={869 - 881}
}
Abstract Extracellular fibrillar amyloid deposits are prominent and universal Alzheimer's disease (AD) features, but senile plaque abundance does not always correlate directly with the degree of dementia exhibited by AD patients. The mechanism(s) and dynamics of Aβ fibril genesis and deposition remain obscure. Enhanced Aβ synthesis rates coupled with decreased degradative enzyme production and accumulating physical modifications that dampen proteolysis may all enhance amyloid deposit formation… 
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